At Knox Aesthetics in Knoxville, TN, our goal is to help patients look and feel their best, and one way we do that is by offering an anti-aging treatment with neuromodulators. We offer two of the most popular and effective wrinkle-relaxing products: BOTOX® and Xeomin®. These injectables can make a significant difference in the appearance of expression lines and promote younger and smoother-looking skin.

What Are Neuromodulators?

Neuromodulators are injectable neurotoxins that work by relaxing the muscles at the injection sites to accomplish different cosmetic and medical purposes. While they are primarily used as a temporary yet long-lasting solution for expression lines on the upper half of the face, they can also accomplish different medical goals to alleviate symptoms and improve quality of life.

Once injected into the treatment area, they relax specific muscles for several months at a time. These FDA-approved injectables provide a safe solution for those who want to treat medical conditions like hyperhidrosis or smooth expression lines in one or more areas of their faces.

What Are the Treatment Benefits?

Both BOTOX® and Xeomin® are safe injectables that temporarily reduce the appearance of expression lines in multiple facial areas. Some of the most well-known treatment benefits include the following:

  • Treatments are quick and only take minutes to complete
  • Results appear in less than a week
  • Results last three to six months
  • Regular treatments promote long-term results
  • Injections are virtually painless
  • Treatments are versatile
  • There’s no downtime
  • Injections can be combined with other cosmetic treatments


BOTOX® is the most commonly used and well-known cosmetic injectable available. It was the first injectable of its kind to safely treat expression lines and still is the only FDA-approved product to smooth expression lines in three different areas of the face. It can smooth frown lines, crow’s feet, and forehead lines. We can also customize a BOTOX® treatment specifically designed for men, called Bro-tox, to subtly smooth expression lines and promote a younger and well-rested-looking appearance.

Results appear within the first week, typically after three to four days. The best results are most visible 30 days after initial treatment. Depending on how quickly the body metabolizes the active ingredients in BOTOX®, patients can expect to enjoy results for approximately three to four months, and sometimes longer.

Using BOTOX® for Medical Purposes

We can use both BOTOX® to treat hyperhidrosis, a condition that affects many men and women and causes profuse sweating, typically from the underarms. Injections into specific areas will block sweat glands to reduce total sweat, which can improve patient confidence long-term.


Xeomin® is another neuromodulator that works similarly to BOTOX®. What differentiates it from BOTOX® and other similar products is that it uses a highly purified formula with no added proteins to smooth the expression lines between the eyebrows, referred to as frown lines. Results typically appear within the first two to three days of treatment and last three to four months.

Frequently Asked Questions

How Many Treatments Will I Need?

Most patients need one initial treatment to achieve the desired results. Regular follow-up treatments are necessary every few months, as these products do only deliver temporary results.

What Happens If I Need To Temporarily Stop My Treatments?

Many patients must temporarily stop treatments with neurotoxins for different reasons, most often before and during pregnancy and while nursing. Doing so does not lead to any negative effects.

Once you stop treatment, your expression lines will gradually reappear as your body metabolizes the product. When it’s out of your system, your expression lines will look like they did before the treatment. Once you’re ready, you can resume treatments to once again achieve wrinkle-free skin.

Are Neuromodulators Right for Me?

Patients who want to address visible expression lines, whether mild, moderate, or more severe, on the upper half of their faces make good candidate neuromodulators. Neuromodulators also provide a solution for those who have tried other treatments and anti-aging skin care products in an effort to reduce expression lines but haven’t achieved dramatic or noticeable results. While most patients qualify for treatment, some may not be good candidates for safety reasons.

Pregnant and nursing women do not qualify for treatment, nor do those allergic to any ingredients in BOTOX® or Xeomin®. We conduct pre-treatment consultations to learn more about each patient’s treatment goals, discuss their medical history, and consider any experience they have had with neurotoxins in the past to confirm treatment eligibility.

Is There Any Downtime?

Not only do these products deliver a quick, minimally invasive treatment, but there’s also no significant downtime. Patients can expect to resume normal daily activities after their appointment so long as they are mindful of temporarily avoiding certain activities, products, and environments.

It’s important that patients keep their heads elevated for several hours after the appointment, avoid hot environments and strenuous workouts for the first 24 hours, and avoid touching the treatment site. It’s also recommended that patients avoid harsh topical products near the injection site for the first few days following treatment.

Learn More About How You Can Benefit From Neuromodulators

Whether you want to finally resolve the symptoms of hyperhidrosis or soften expression lines to achieve a younger-looking appearance, we can design a treatment plan that’s right for you. We can evaluate your treatment areas, determine whether BOTOX® or Xeomin® will meet your needs, and begin the treatment process so you can experience all the long-term benefits of adding one or both of these injectables to your cosmetic routine.

Dermal fillers can subtly enhance the features and temporarily reverse some of the most common sides of aging, including the development of hollow areas, facial folds, lines, and wrinkles. At Knox Aesthetics in Knoxville, TN, we offer several of the most popular and effective fillers to improve facial aesthetics and reverse aging. The right combination of fillers may be exactly what you need to accomplish what your anti-aging products cannot.

What Are Dermal Fillers?

Dermal fillers are cosmetic injectables specifically designed to improve the appearance. They can augment the lips, enhance features, correct facial proportions, and reverse the common signs of aging. We offer three primary types of fillers, hyaluronic acid-based gel fillers, biostimulators, and PRF injections. Biostimulators contain active ingredients that force the body to respond to their presence beneath the skin with increased collagen production.

Hyaluronic acid-based fillers use a gel that contains synthetic hyaluronic acid particles, similar to what the body naturally produces, to immediately inject volume into different areas to enhance, augment, fill, and plump. PRF injections use the natural healing and regenerative properties of your blood to increase volume and combat aging.

What Are the Benefits?

There are many benefits to beginning a treatment plan with dermal fillers. These products can do what many topical solutions cannot and enable patients to enjoy their ideal results for a significant amount of time. Some of the other treatment benefits include the following:

  • Results look natural
  • Results are long-lasting
  • Treatment times are quick and convenient
  • Treatments are versatile and customizable
  • Injectables are FDA-approved as safe for use in multiple facial areas

The JUVÉDERM® Collection

The JUVÉDERM® Collection includes six different fillers that can treat different areas of the face. These products contain lidocaine to enhance comfort during the injection process and post-treatment.

JUVÉDERM® fillers can enhance the lips, augment the cheeks, improve the aesthetics of the chin, fill hollow areas, contour the jawline, and smooth lines and wrinkles that form on the lower and middle half of the face. Patients typically need treatments every one to two years to maintain results, and treatments can take less than 30 minutes from start to finish.


JUVÉDERM® VOLUMA® XC is a cheek filler from this collection that can add volume to contour the cheeks and lift the area. After an initial treatment, results can last up to two years. We can also use this filler to augment the chin profile to improve facial proportions and aesthetics. When injected into the chin, results last up to one year.


JUVÉDERM® VOLLURE® XC is a filler that can smooth lines that form around the mouth, including laugh lines of different severities. Results can last up to 18 months post-treatment.


JUVÉDERM® ULTRA PLUS XC is a filler made with a thicker formula specifically designed for patients with the more advanced signs of aging, including deep lines around the nose and mouth. Post-treatment, results can last up to 18 months.


JUVÉDERM® VOLBELLA® XC can augment lips to reverse aging or increase natural-looking volume. After an initial treatment, results last up to one year.


JUVÉDERM® ULTRA XC is another filler that can add volume to the lips and smooth lines around the mouth. After an initial treatment, results can last up to one year.


JUVÉDERM® VOLUX XC is a filler from the JUVÉDERM® collection that can contour the jawline by creating a more aesthetically pleasing and balanced jawline for those who want a more sculpted appearance. Results typically last one year after treatment.


RADIESSE® is a collagen-stimulating filler and biostimulator and contains an active ingredient called CaHA that stimulates the body to produce increased collagen at the treatment sites. We can use this biostimulator to force your body to increase collagen production and produce its natural filler in different areas of the lower and middle half of the face, including areas where smile lines form and run from the outer corner of the nose to the lower part of the mouth.

We can also use it to treat pre-jowl folds, smile lines, chin wrinkles, and nasolabial folds. RADIESSE® can also restore a youthful appearance to the backs of the hand and contour the jawline naturally.


BELOTERO BALANCE® is a hyaluronic acid-based dermal filler that is designed to smooth wrinkles and facial folds that form on the lower and middle half of the face. We can use it to smooth nasolabial folds, chin, wrinkles, smile lines, and even lip lines that form above the mouth. Treatments deliver immediate results and typically last six months or longer based on the injection areas.

PRF Injections

PRF injections provide an alternative treatment option for patients not ready to commit to dermal fillers to achieve their ideal appearance. However, they can also be combined with dermal fillers to promote anti-aging results. PRF stands for platelet-rich fibrin and is derived from the blood through a standard pre-treatment blood draw.

How It Works

PRF contains growth factors and regenerative qualities released after treatment to increase collagen production, renew the skin, fight natural aging, and promote cellular renewal and regeneration. This natural filler can be used as a preventative treatment and as a prescriptive one to address visible aging in different facial areas.

After an initial treatment, it can take several weeks to see the treatment effects as the body produces increased collagen at the treatment sites in response to the platelet-rich fibrin injections. Results can last months to years, and regular treatments can extend those results long-term.

Reverse Aging and Rejuvenate Your Appearance With a Dermal Filler Treatment Plan

Whether you want to improve facial aesthetics and proportions to achieve your ideal appearance or combat aging, we can design a dermal filler treatment plan for you. We can schedule a consultation to evaluate your treatment areas, confirm that you’re a good candidate, and design your treatment plan; then, we can administer the right filler or combination of fillers to help you feel more confident and experience the benefits of this rejuvenating treatment.